Doha – June 23, 2024: Researchers at Weill Cornell Medicine-Qatar (WCM-Q) have made new discoveries about the complex metabolic and genetic processes which drive the formation of new fat cells, shedding light on the possible causes of obesity and its complications, such as inflammation and metabolic diseases like type 2 diabetes.
Using CRISPR gene editing technology, the researchers demonstrated that a protein called UHRF1 plays a key role in the regulation of the formation of new fat cells, known as adipogenesis. They also showed that the UHRF1 protein suppresses fibrosis, which is the hardening or scarring of bodily tissues and is a cha